Quote:
Originally Posted by Pitchwife
Nope. As far as we know, only Saruman ever cross-bred Men and Orcs; otherwise the Orcs multiplied like the Children of Ilúvatar, i.e. took care of their own breeding without need for special intervention.
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That is up for conjecture. Sauron bred the Uruk-hai in the 3rd Age, a much larger breed than any previous Orc. Such a noticeable size variation in a fairly stable stock would indicate cross-breeding, as far as my genetic knowledge goes.