The Uruk Hai, a blended race, to mirror what Melkor did to the Elves (debate about Tolkien's refinement of this area aside later in his life). That's pretty perverse. On the verge of making new Rings. I.e. from hero Istari to replicator of the greatest of evils in Arda's history.
Those two deeds, imo, place Saruman as serioulsy at odds with the Valar, and in an irredemable place.
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