Khamul's job was probably just to "hold" Dol Guldur against any attacks by the White Council, and keep sending Orcs for reinforcements, raids, etc. I don't think Sauron was planning anything major in that sector of the playing field. His mind was entirely concentrated on Gondor, for that was where the first stroke would fall. Later, he thought that Gondor had the One Ring, so he doubled his assault there, ignoring, for the most part, the other parts of Eriador.
Except, of course, the Assault on the Lonely Mountain. I've always wondered whether the Orcs from that assault came from Dol Guldur or from Barad-dur. They would have needed a leader and some form of organization, so perhaps Sauron sent another "minor lieutenant" there, maybe even that messenger that he had already sent to Dain.
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But Melkor also was there, and he came to the house of Fëanor, and there he slew Finwë King of the Noldor before his doors, and spilled the first blood in the Blessed Realm; for Finwë alone had not fled from the horror of the Dark.
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