Interesting.
(What about Miruvor, speaking of draughts?)
Frodo was given some Orc-draught in Cirith Ungol, was he not?
Merry and Pippin were not incapable of subterfuge prior to Amon Hen; recall "A Conspiracy Unmasked, " and Merry spying on Bilbo to learn about the Ring.
Still, interesting topic. If your theory is true, I wonder if Frodo's orc-draught might have weakened his resistance to the darkness in some way.
On scriptural principle, I would argue against the negative spiritual eefects of the orc-draught-- were it not for Tolkien's clear intent to show the positive spiritual effects of the Lembas.
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...down to the water to see the elves dance and sing upon the midsummer's eve.
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