Voice of Smaug?

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Originally Posted by Bêthberry

Ah, this raises an interesting question, above and beyond the actor's identity. Just which kind of English accent would be appropriate for Smaug?

Reading a bit about Hugh Laurie (he plays Dr. House on the TV show of the same name), I learned the following:

Originally Posted by wikipedia

Although Laurie has been a household name in many parts of the world since the 1980s, he only came to the attention of a broader American public in 2004, when he first starred as the acerbic attending physician Dr. Gregory House in the popular FOX medical drama House. For his portrayal, Laurie assumes an American accent. Laurie was in Namibia filming Flight of the Phoenix and recorded the audition tape for the show in the bathroom of the hotel, the only place he could get enough light. His US accent was so convincing that executive producer Bryan Singer, who was unaware at the time that Laurie is English, pointed to him as an example of just the kind of compelling American actor he had been looking for.

..meaning that to have a British accent, we need not look just to British actors.

And that said, must we exclude female voices a priori? Is Smaug male? What does 'male' mean in dragon form? Could not a woman's voice work as well?